Brain tumor is a sequence-specific RNA-binding protein that directs maternal mRNA clearance during the Drosophila maternal-to-zygotic transition

Table 3 Summary of comparisons of BRAT- and PUM-associated mRNAs to genome-wide mRNA translation and stability datasets

	All PUM-associated mRNAs	mRNAs associated only with PUM	All BRAT-associated mRNAs	mRNAs associated only with BRAT	PUM and BRAT co-target mRNAs
Translational repression
Lower than expected translation index
Chen et al., 2014 [44]^a	+++	++	+++++	++++	+++
Enriched for translationally inactive mRNAs
Qin et al., 2007 [57]^b	.	.	+++	+++	.
Depleted of translationally active mRNAs
Qin et al., 2007 [57]^b	.	.	++++	++++	+
mRNA degradation
Degraded in early embryos:
De Renzis et al., 2007 [58]^b	.	.	++++	++++	.
Thomsen et al., 2010 [59]^b	+++	.	+++++	+++++	+++
Fly-FISH database ^c	+	+	+++	+++	.
Degraded from 0 to 2 h to 2 to 4 h (modENCODE RNAseq)^a	.	.	+++++	+++++	.
Degraded via maternal degradation machinery
Tadros et al., 2007 [60]^b	.	.	++++	++++	.
Thomsen et al., 2010 [59]^b	.	.	+++	+++	.
Degraded via zygotic degradation machinery
Thomsen et al., 2010 [59]^b	+++	+	+++	+++	+++

+ P = 0.01 to 0.05; ++ P = 0.001 to 0.01; +++ P = 10⁻¹⁰ to 0.001; ++++ P = 10⁻¹⁰ to 10⁻³⁰; +++++ P <10⁻³⁰; ‘.’ = not significant.
^a P values are Wilcoxon Rank Sum test. Also see Figure 6.
^b P values are Benjamini-Hochberg corrected Fisher’s exact test (that is, FDR). For complete details of comparisons see Additional file 10.
^c P values are Benjamini-Hochberg corrected Fisher’s exact test (that is, FDR). For details of comparisons see Additional file 9.

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