Skip to main content

Table 3 Summary of comparisons of BRAT- and PUM-associated mRNAs to genome-wide mRNA translation and stability datasets

From: Brain tumor is a sequence-specific RNA-binding protein that directs maternal mRNA clearance during the Drosophila maternal-to-zygotic transition

  All PUM-associated mRNAs mRNAs associated only with PUM All BRAT-associated mRNAs mRNAs associated only with BRAT PUM and BRAT co-target mRNAs
Translational repression      
Lower than expected translation index      
Chen et al., 2014 [44]a +++ ++ +++++ ++++ +++
Enriched for translationally inactive mRNAs      
Qin et al., 2007 [57]b . . +++ +++ .
Depleted of translationally active mRNAs      
Qin et al., 2007 [57]b . . ++++ ++++ +
mRNA degradation      
Degraded in early embryos:      
De Renzis et al., 2007 [58]b . . ++++ ++++ .
Thomsen et al., 2010 [59]b +++ . +++++ +++++ +++
Fly-FISH database c + + +++ +++ .
Degraded from 0 to 2 h to 2 to 4 h (modENCODE RNAseq)a . . +++++ +++++ .
Degraded via maternal degradation machinery      
Tadros et al., 2007 [60]b . . ++++ ++++ .
Thomsen et al., 2010 [59]b . . +++ +++ .
Degraded via zygotic degradation machinery      
Thomsen et al., 2010 [59]b +++ + +++ +++ +++
  1. + P = 0.01 to 0.05; ++ P = 0.001 to 0.01; +++ P = 10−10 to 0.001; ++++ P = 10−10 to 10−30; +++++ P <10−30; ‘.’ = not significant.
  2. a P values are Wilcoxon Rank Sum test. Also see Figure 6.
  3. b P values are Benjamini-Hochberg corrected Fisher’s exact test (that is, FDR). For complete details of comparisons see Additional file 10.
  4. c P values are Benjamini-Hochberg corrected Fisher’s exact test (that is, FDR). For details of comparisons see Additional file 9.