Brain tumor is a sequence-specific RNA-binding protein that directs maternal mRNA clearance during the Drosophila maternal-to-zygotic transition

Table 2 Summary of Fly-FISH localization patterns enriched among BRAT- and PUM-associated mRNAs

	All PUM-associated mRNAs	mRNAs associated only with PUM	All BRAT-associated mRNAs	mRNAs associated only with BRAT	PUM and BRAT co-target mRNAs
Embryonic stages 1 to 3 localization patterns
Posterior localization	+	.	++	.	++
Nuclei-associated/Perinuclear	+	.	++	.	++
Embryonic stages 4 to 5 localization patterns
Segmented/Gap-gene localization	+++	+++	.	.	.
Patterns indicative of zygotic transcription	+++++	++++	.	.	+
Perinuclear around yolk nuclei	+	+	.	.	.
Cell division apparatus	+	+	.	.	.
Apical enrichment	+	+	.	.	.
Pole cell enrichment	.	.	+	.	.
Yolk plasm localization	.	.	.	+	.

+ FDR = 1% to 10%; ++ FDR = 0.1% to 1%; +++ FDR = 0.001% to 0.1%; ++++ FDR = 10⁻⁵% to 0.001%; +++++ FDR <10⁻⁵%; ‘.’ = not significant (FDR >10%). FDR values indicated represent the most significantly enriched term related to the localization pattern listed. For details see Additional file 9.

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