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Table 1 Summary of gene annotation enrichment analyses of BRAT- and PUM-associated mRNAs

From: Brain tumor is a sequence-specific RNA-binding protein that directs maternal mRNA clearance during the Drosophila maternal-to-zygotic transition

  All PUM-associated mRNAs mRNAs associated only with PUM All BRAT-associated mRNAs mRNAs associated only with BRAT PUM and BRAT co-target mRNAs
Biological and developmental
Embryonic pattern specification +++ ++ . . .
Axis specification ++ . + . +
Embryonic morphogenesis/gastrulation ++++ +++ . . .
Formation of organ boundary ++++ ++++ . . .
Imaginal disc development/pattern formation ++++ +++ . . .
Oogenesis/ovarian follicle cell development ++ + . . .
Neuroblast fate determination + . . . +
Tube development/digestive system development/respiratory system development ++ + . . .
Salivary gland development + + . . .
Sensory organ development +++ ++ . . .
Cellular
Cell motility/cell migration +++++ +++ . . +
Neuron projection morphogenesis +++ ++ . . .
Cell division/asymmetric cell division + + . . .
Cell adhesion + + . . .
Regulation of growth/cell size ++ ++ . . .
Regulation of apoptosis + . . . .
Molecular
Signal transduction +++++ ++++ + . +++
Regulation of transcription ++++ +++ . . +
Protein kinase activity ++ . + . .
Phosphatase activity . . + . .
Glycosyltransferase ++ + . . .
Integral membrane proteins ++++ + +++++ +++ +++
Glycoproteins +++ ++ . . .
Ion transport/homeostasis . . +++ ++ +
Phospholipid/phosphoinositide metabolism . . +++ +++ .
  1. + FDR = 1% to 10%; ++ FDR = 0.1% to 1%; +++ FDR = 0.001% to 0.1%; ++++ FDR = 10−5% to 0.001%; +++++ FDR <10−5%; ‘.’ = not significant (FDR >10% and Benjamini P value >0.1). FDR values represent the most significantly enriched annotation term related to the function listed. Analyses were performed using the DAVID functional annotation tool [42,43]. For details see Additional file 8.