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Figure 1 | Genome Biology

Figure 1

From: Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification

Figure 1

HER2 heterogeneous breast cancers are ER-positive and preferentially TP53 mutant. (A) Clinico-pathologic characteristics of HER2 heterogeneous breast cancers included in this study. ER, estrogen receptor; PR progesterone receptor; WT, wild-type. (B) Micrographs of representative hematoxylin and eosin (H&E) stained sections, HER2 immunohistochemistry (IHC) and HER2 chromogenic in situ hybridization (CISH) of selected HER2 heterogeneous breast cancers included in this study (scale bar IHC, 200 μm; scale bar CISH, 50 μm). Chromosome 17 plots of microdissected HER2-positive and HER2-negative components of each case confirming the presence and absence of HER2 gene amplification (17q12), respectively. In the chromosome plots, the circular binary segmentation (cbs)-smoothed Log2 ratios for each bacterial artificial chromosome mapping to chromosome 17 were plotted on the y-axis and their genomic positions were plotted on the x-axis. Gains, amplifications and losses are highlighted in dark green, bright green and red, respectively. Please see Additional file 2 for the remaining cases.

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