Figure 5
From: Oxygen and glucose deprivation induces widespread alterations in mRNA translation within 20 minutes
Ribosome profiles exhibiting mRNA-specific OGD-induced features. (A) Selected mRNAs whose ribosome densities increase at uORFs and decrease at acORFs during OGD. Ribosome profile for Eif1a mRNA is used as the legend. (B) Upregulation of parathymosin isoform with amino-terminal extension whose synthesis begins at a non-AUG codon. (C) Increased uORF density at Eif1b mRNA coincides with decreased density at the acORF and non-annotated downstream ORF. (D) Increased ribosome density downstream of Romo1 acORF that may occur as a result of translation of a long overlapping ORF. (E) Ribosome stalling or an abortive translation event at Srpr mRNA.