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Table 3 Topological ancestor–descendant and sibling relationship reconstruction on simulated data in the presence of copy number variants

From: Fast and scalable inference of multi-sample cancer lineages

Samples Trees % SSNVs % AD % AD-Ord % AD-Corr % AD →Sib (−priv) % Sib % Sib-Corr % Sib →AD (−priv)
5 95 96.2 89.1 14.4 93.7 20 (0.4) 92.6 80.8 2.4 (0)
  98 97.42 91.96 10.74 96.1 0.20 94.85 80.46 2 (0.02)
10 91 94.8 77.1 14.6 93.5 24.9 (0.6) 90.9 91.8 1.3 (0)
  92 94.55 78.97 11.95 93.1 0.41 90.5 91.7 1.1 (0.01)
15 97 91.8 65.9 11.1 92.5 23.3 (0.4) 85.5 94.6 0.7 (0)
  94 92.9 69.6 10.8 94.5 24.2 (0.35) 87.5 94.8 0.6 (0.01)
  1. Results are shown for 5, 10, and 15 samples given 1,000 × coverage data obtained with localized (top row in each pair) and randomized (bottom row) sampling with approximately 80% of SSNVs in CNV regions. All values are averaged over the number of reconstructed trees. AD, ancestor–descendant; CNV, copy number variant; Corr, correctly ordered; Cov, coverage; Ord, ordered; priv, private mutation nodes; Sib, sibling; SSNV, somatic single nucleotide variant.