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Table 3 Topological ancestor–descendant and sibling relationship reconstruction on simulated data in the presence of copy number variants

From: Fast and scalable inference of multi-sample cancer lineages

Samples

Trees

% SSNVs

% AD

% AD-Ord

% AD-Corr

% AD →Sib (−priv)

% Sib

% Sib-Corr

% Sib →AD (−priv)

5

95

96.2

89.1

14.4

93.7

20 (0.4)

92.6

80.8

2.4 (0)

 

98

97.42

91.96

10.74

96.1

0.20

94.85

80.46

2 (0.02)

10

91

94.8

77.1

14.6

93.5

24.9 (0.6)

90.9

91.8

1.3 (0)

 

92

94.55

78.97

11.95

93.1

0.41

90.5

91.7

1.1 (0.01)

15

97

91.8

65.9

11.1

92.5

23.3 (0.4)

85.5

94.6

0.7 (0)

 

94

92.9

69.6

10.8

94.5

24.2 (0.35)

87.5

94.8

0.6 (0.01)

  1. Results are shown for 5, 10, and 15 samples given 1,000 × coverage data obtained with localized (top row in each pair) and randomized (bottom row) sampling with approximately 80% of SSNVs in CNV regions. All values are averaged over the number of reconstructed trees. AD, ancestor–descendant; CNV, copy number variant; Corr, correctly ordered; Cov, coverage; Ord, ordered; priv, private mutation nodes; Sib, sibling; SSNV, somatic single nucleotide variant.