Figure 4From: Age and sun exposure-related widespread genomic blocks of hypomethylation in nonmalignant skinBlocks identified in photoaged skin are more hypomethylated in squamous cell cancer (SCC). (A) Distribution of methylation values in 450k probes measuring CpGs within the identified age- and sun exposure-associated blocks. (B) Distribution of methylation values in 450k probes measuring CpGs outside of the identified age- and sun exposure-associated blocks. (C) Distribution of methylation values in 450k probes measuring CpGs within open sea regions and within the identified age- and sun exposure-associated blocks. (D) Distribution of methylation values in 450k probes measuring CpGs within open sea regions and outside the identified age- and sun exposure-associated blocks. (E) Heatmap showing mean methylation in blocks identified comparing O-exp and Y-pro epidermis. Samples and blocks are ordered by hierarchal clustering. Yellow/red indicate higher/lower methylation, respectively.Back to article page