Figure 1
From: Age and sun exposure-related widespread genomic blocks of hypomethylation in nonmalignant skin
DNA methylation in epidermal but not dermal samples clusters by age and sun exposure. (A) In epidermis, DNA methylation segregates old versus young individuals, and also segregates sun-exposed and sun-protected anatomical regions, shown by multidimensional scaling of pairwise distances derived from methylation levels assayed on the HumanMethylation450 BeadChip (450k). (B) In dermis, DNA methylation does not segregate samples by age or anatomical region, shown by multidimensional scaling of pairwise distances derived from methylation levels assayed on the 450k.