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Figure 4 | Genome Biology

Figure 4

From: Temporal and technical variability of human gut metagenomes

Figure 4

Nearest neighbor plot. The mOTU abundances of the fecal metagenomes of the time series and replicates were clustered in the context of 888 published metagenomes. Only the 14 nearest neighbors (NN) are shown for visual clarity. The colored boxes indicate the respective subject. Non-self samples (samples from another subject, including HMP and MetaHIT) are shaded in grey. Subjects are color-coded, sampling time points are indicated and text color corresponds to the preservation condition of each sample (see key). The column on the right shows how many NNs of each respective sample are depicted, indicating the subject-specificity of the clustering (complete linkage clustering based on Euclidean distances). The figure shows that, with very few exceptions, all time series samples and all fecal replicates (from d7 and d392) from one subject were closer to each other than to any other sample from another subject. Pre-treatment samples from subject Alien were nearest neighbors to each other while the samples right after the treatment (d376–380) had highest similarity to each other but not to the pre-treatment samples. The samples collected long after the treatment (d600–773) were most similar to each other but a slow recovery to the pre-antibiotics state was visible since pre-treatment samples are among the 14 neighbors shown.

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