Expression of genes exhibiting at least a 16-fold difference in expression between any two developmental stages and grouped by hierarchical clustering. (a) Heatmap with upregulation in blue and downregulation in red relative to metacercariae. Colours to left of heatmap correspond to different clusters. (b) Expression of genes within each cluster on a log2 scale. The number of genes and the enrichment of biological processes are shown for the most specific terms within the gene ontology structure and with a significance of <0.1%. GO:0006508 Proteolysis is shown in brackets for clusters where it appears with a significance of 0.1% < P < 1%.