Skip to main content
Figure 5 | Genome Biology

Figure 5

From: Denoising perturbation signatures reveal an actionable AKT-signaling gene module underlying a poor clinical outcome in endocrine-treated ER+ breast cancer

Figure 5

Kaplan–Meier survival analysis of the AKT gene module in ER+ breast cancer.(A) Kaplan–Meier curves of the endocrine-treated ER+ patients in the METABRIC set as well as for the datasets of Loi et al. [20] and Zhang et al. [30], with samples stratified according to the lower, intermediate and upper tertiles of the AKT module activation score. Number of samples in each tertile is indicated. Hazard ratios, 95 % confidence intervals and Cox regression P values between lower and higher tertiles are given. (B) As (A) but for the untreated ER+ patients of the METABRIC set, as well as the untreated ER+ patients of Wang et al. [29] and Miller et al. [31]. Untreated here means no endocrine therapy or chemotherapy, but may include radiotherapy. ER+, estrogen receptor positive; HR, hazard ratio; MB, METABRIC; Prob, probability; OS, overall survival; DM, distant metastasis.

Back to article page