Figure 6

Interferon-β1b (IFN-β1b) therapy corrects aberrant levels of TROVE2, SSB, poly (A) + Y1 RNA, and poly(A) + U1 snRNA in RRMS. Blood samples were collected in PaxGene tubes from CTRL (N = 12), RRMS subjects not on IFN-β1b (RRMS - IFN-β1b, N = 12), and RRMS subjects on stable IFN-β1b therapy (RRMS + IFN-β1b, N = 4). Oligo dT was used for cDNA synthesis. Transcript levels of TROVE2 and SSB (A) or poly(A) + Y1 RNA and poly(A) + U1 RNA (B) were determined by quantitative PCR and normalized to CTRL = 1 after normalization to levels of GAPDH. Error bars are ± S.D. *P <0.05.