Figure 2From: Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy CRC antigenome comprising two antigen classes: cancer-germline antigens and neo-antigens. (A) Two-dimensional hierarchical clustering of the expression of cancer-germline antigens calculated from the RNA sequencing data for the three molecular phenotypes (MSS, MSI-H and MSS^). All displayed matrix elements met the threshold as described in Methods. Genes marked in bold were significantly higher expressed in a specific patient group. (B) Two-dimensional hierarchical clustering of neo-antigens, that is, identical peptides shared in more than two patients in the three groups. Highlighted are most frequent neo-antigens in the specific group and the corresponding mutated gene. (C) Neo-antigen frequencies from stage I to stage IV in MSS, MSI-H and MSS^ patients. (D) Survival analysis for the number of immunogenic missense and frameshift mutations in all CRC patients.Back to article page