CopywriteR outperforms exonic depth of coverage-based methods. (A) Tumors from a breast cancer mouse model were subjected to WES or LC-WGS, and analyzed using CopywriteR or onTarget methods. Subsequently, copy number data were segmented using propSeg or CBS, while the integrated EXCAVATOR tool was used in addition. Weighted Euclidian distances (left) and Pearson correlation coefficients (right) were calculated between the different approaches for every sample, and the means of those values across all samples are represented as clustered heatmaps. (B) As in (A); the genome-wide copy number plots for sample T3 are displayed for the indicated analysis methods, with segmentation values depicted in red.