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Figure 1 | Genome Biology

Figure 1

From: Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations

Figure 1

Distribution of CDKN2A, CDK4 and RB1 mutations and copy number changes. These are from the The Cancer Genome Atlas (TCGA) glioblastoma dataset, as provided by cBioPortal. At least one of the genes is altered in 78% of the cases, with an overlap in only two samples. Even though RB1 is mutated only in 11% of the cases, its activity is potentially affected by alterations of the other two genes, which encode for upstream proteins in the signaling network.

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Genome Biology

ISSN: 1474-760X

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