Skip to main content

Table 1 KEGG functions enriched for genes correlated with AGS

From: Average genome size estimation improves comparative metagenomics and sheds light on the functional ecology of the human microbiome

KEGG function Hierarchy level Direction of correlation q -value
Metabolism A Positive 0
Metabolism of cofactors and vitamins B Positive 0
Amino acid metabolism B Positive 0
Carbohydrate metabolism B Positive 0
Glycan biosynthesis and metabolism B Positive 2.7E-05
Two-component system C Positive 0
Biosynthesis of amino acids C Positive 0
Glycosaminoglycan degradation C Positive 1.50E-06
Pentose and glucuronate interconversions C Positive 1.07E-05
Lipopolysaccharide biosynthesis C Positive 2.21E-05
Histidine metabolism C Positive 2.24E-05
Fructose and mannose metabolism C Positive 2.69E-05
Carbon metabolism C Positive 2.75E-05
Alanine, aspartate and glutamate metabolism C Positive 2.89E-05
Biotin metabolism C Positive 7.68E-05
Membrane transport B Negative 1.0E-05
Drug resistance B Negative 6.9E-03
Peptidoglycan biosynthesis C Negative 9.5E-10
ABC transporters C Negative 2.3E-05
Pyruvate metabolism C Negative 7.3E-05
  1. Functions within the BRITE hierarchy were tested for enrichment, using the cumulative hypergeometric test, for genes that were strongly correlated with AGS (Pearson q < 1e-5). This was performed separately for genes that were positively correlated and genes that were negatively correlated. Listed are the most significant results from this analysis.