Skip to main content
Figure 7 | Genome Biology

Figure 7

From: DGEclust: differential expression analysis of clustered count data

Figure 7

Comparison of ROC curves for different methods. The methods were applied to CAGE data from different regions of the human brain. A ground truth was established as in Figure 6. DGEclust is top-ranked in all cases. All methods demonstrate excellent performance, achieving a TPR larger than 0.8 at FPRs less than 0.01. As indicated by the Venn diagrams constructed from DE genes obtained at an FDR equal to 0.1%, the three methods demonstrate a significant overlap, sharing more than 1K genes in most cases. In terms of the number of novel discoveries (i.e. DE genes identified as such only by a particular method), DGEclust occupies the middle spot between DESeq2 (first) and edgeR (third). CAGE, cap analysis of gene expression; DE, differentially expressed; FDR, false discovery rate; FPR, false positive rate; hippocamp., hippocampus; ROC, receiver operating characteristic; TPR, true positive rate.

Back to article page