PhyloWGS run time. Relationship between the number of SSMs in the simulated dataset with five subpopulations and the run time on a log10 vs log10 plot. Run time was measured using a single core of an Intel i7-4770K with 2,500 MCMC iterations and 5,000 inner Metropolis–Hastings iterations. The run time can be greatly decreased by parallelizing the sampling or by taking less samples; however, the implications of these options have not been explored. SSM, simple somatic mutation.