Figure 10
From: PhyloWGS: Reconstructing subclonal composition and evolution from whole-genome sequencing of tumors
Expert-generated and inferred phylogenies for patient CLL077 with chronic lymphocytic leukemia. Left: The expert-generated phylogeny based on targeted deep-sequencing data. Right: The phylogeny inferred by PhyloWGS on allele frequencies of the same SSMs found using WGS. The subclonal lineage population frequencies for the five samples and the SSM assignments of lineages are also shown in the figure. SSM, simple somatic mutation; WGS, whole-genome sequencing.