Figure 1From: PhyloWGS: Reconstructing subclonal composition and evolution from whole-genome sequencing of tumors The development of intratumor heterogeneity and subclonal reconstruction. Tumor composition over time (i), the resulting distribution of variant allele frequencies (VAFs) (ii), the result of successful inference of the VAF clusters (iii), and the desired output of subclonal inference (iiii). SSM, simple somatic mutation; VAF, variant allelic frequency.Back to article page