Figure 8

Global scenario of multiple associations at different molecular levels. (A) Network representation with tumor pathophenotypes (red octagons), tumor and liver cell signaling (yellow and blue squares, respectively), serum markers from mass spectrometry (gray circles) and clinical biochemical markers (green circles). Red edges indicate a negative correlation, green edges a positive correlation. All simple correlations with P < 0.05 and r > 0.3 were included. The Cystoscape document with all this information is included as Additional file 4. It should be opened with Cystoscape version 3.1.0. Readers can zoom in on and visualize all specific associations with the freely available Cytoscape software (see Material and methods section). (B,C) We constructed prognostic indices with the variables that predicted tumor latency (B) and duration of disease or survival with tumor (C). In both models, mice were ranked according to their risk score and divided into two groups (good and poor risk) using the median risk score as cutoff. We show additional information in Table S22 in Additional file 1. The genetic markers used in these prognostic indices were gnf13.057.501 in tQTL 3, rs4231934 in tQTL 4, rs6193859 in tQTL 1, rs3696018 in tQTL 8, and rs13481230 in tQTL 11. ManNAc, N-acetyl-D-mannosamine.