Genomic regions associated with tumor behavior. (A) Distribution of QTLs associated with different tumor pathophenotype (tQTL) variability across different mouse chromosomes. The color intensity reflects the LOD score level. LOD scores <1.5 are homogenously represented in gray. Detailed information concerning these results is reported in Table S4 in Additional file 1. (B) Effect on tumor latency of different loci identified by the Kaplan-Meier estimator. F/F indicates FVB homozygous and F/C indicates FVB/C57 heterozygous at those loci. (C) Distinction of all the clinical prognosis clusters defined at the genetic level. The figure shows the percentage of mice with a particular heterozygous genetic marker differentially present in the five clusters of mice based on prognosis. The genetic markers and percentages represented can be found in Table S5 in Additional file 1b.