Figure 2

Spectacle results for cell line GM12878 for 20 chromatin states. (Left) Emission matrix and state annotation (values between 0 and 1 are colored from white to black). (Middle) Number of genomic segments and distance from TSS of the segments for each state. The distribution bars are shown only when at least 10% of the segments are within 5 kb from the TSS (the percentage of the segments within 5 kb from the TSS is shown by the color of the distribution bars, i.e., the more segments within 5 kb from the TSS, the bluer the distribution bars are). (Right) Enrichment of validated biological features (enrichment is colored red and depletion is colored blue). CpGI, CpG island; DRM, gene-distal regulatory module; Enh, strong enhancer; EnhP, poised enhancer; EnhW, weak enhancer; kb, kilobase; Num, number; Pol2, RNA polymerase II binding; PRM, promoter-proximal regulatory module; Prom, strong promoter; PromF, promoter flanking; PromP, poised promoter; PromW, weak promoter; Repr, repressed region; TSS, transcription start site; Txn, transcribed region.