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Figure 6 | Genome Biology

Figure 6

From: Identifying candidate drivers of alcohol dependence-induced excessive drinking by assembly and interrogation of brain-specific regulatory networks

Figure 6

Administration of the GR antagonist mifepristone (RU38486) in either the NAc or VTA selectively decreased alcohol self-administration in rats with a history of alcohol dependence (dep) during protracted abstinence. The rats were made dependent on alcohol by chronic, intermittent vapor exposure and then removed from the vapor chambers. Non-dependent rats were not exposed to alcohol vapor (nondep). The rats were prepared with guide cannulae for bilateral injections of mifepristone (30 μg/0.3 μL/side) or vehicle into the nucleus accumbens and ventral tegmental area. The rats were tested for alcohol self-administration during protracted abstinence (1 to 2 months post-vapor) 90 min after mifepristone administration. The data represent mean and standard error. # P <0.05, significant difference from vehicle-treated non-dependent rats. *P <0.05, significant difference from vehicle-treated dependent rats. n = 7 per group.

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