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Table 4 Sibling sex ratios of families with probands with SD or non-SD AIDs

From: Copy number variation in Y chromosome multicopy genes is linked to a paternal parent-of-origin effect on CNS autoimmune disease in female offspring

Autoimmune disease

Sexual dimorphism

Male

Female

Sex ratio

Multiple sclerosis

F > M

   

  Jorge Oksenberg (personal communication)

531

1,356

0.39

  Bertrand Fontaine (personal communication)

252

405

0.62

  Sawcer et al. [35]

190

388

0.49

  Ebers et al. [36]

220

366

0.6

Systemic lupus erythematosus

F > M

   

  Aggarwal et al. [5]

3,201

5,434

0.59

  Moorthy et al. [4]

115

181

0.64

Rheumatoid arthritis

F > M

   

  Lindsey Criswell (personal communication) [37]

987

1,633

0.6

  Peter Gregersen (NARAC)

2,032

3,087

0.66

Pauciarticular onset juvenile arthritis

F > M

62

114

0.54

  Moorthy et al. [4]

Systemic onset juvenile arthritis

    

  Moorthy et al. [4]

F = M

32

32

1

Type 1 diabetes

F = M

   

  Patrick Concannon (personal communication)

1,589

1,489

1.07

  John Todd (personal communication)

3,707

3,627

1.07

  1. F, female; M, male.