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Figure 2 | Genome Biology

Figure 2

From: Copy number variation in Y chromosome multicopy genes is linked to a paternal parent-of-origin effect on CNS autoimmune disease in female offspring

Figure 2

B6-ChrY consomic strains exhibiting significant differences in EAE severity compared with B6 mice. Nonlinear regression analysis using the least squares method revealed that, for each strain studied, the disease course elicited fit a sigmoid curve. The significance of the differences in disease course between B6 and each B6-ChrY consomic line was determined by comparing the best-fit values for each line against those of B6 and by two-way ANOVA with an overall adjusted significance threshold of P ≤ 0.0001 for effect of strain followed by Holm-Sidak corrected post hoc multiple comparisons (*P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; ****P ≤ 0.0001).

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