Table 2 Unique and common variants found in the primary tissue and metastasis for each patient in the study
Patient | Synchronous or metachronous | Receipt of chemotherapy prior to surgery for liver metastasis | Variants common to primary and metastasis (number (mean VAF)) | Variants unique to primary tumor (number (mean VAF)) | Total variants in primary (number (mean VAF)) | Percentage of variants in primary found in metastasis | Variants common to primary and metastasis (number (mean VAF)) | Variants unique to metastasis tumor (number (mean VAF)) | Total variants in metastasis | Percentage of variants in metastasis found in primary | Total distinct variants in each patient |
|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Synchronous | Yes | 7 (31%) | 6 (5%) | 13 (19%) | 53.8% | 7 (47%) | 2 (18%) | 9 (40%) | 77.8% | 15 |
2 | Synchronous | No | 11 (29%) | 1 (3%) | 12 (27%) | 91.7% | 11 (42%) | 0 (NA) | 11 (42%) | 100.0% | 12 |
3 | Synchronous | No | 10 (53%) | 0 (NA) | 10 (53%) | 100.0% | 10 (32%) | 2 (15%) | 12 (29%) | 83.3% | 12 |
4 | Synchronous | Yes | 9 (9%) | 3 (8%) | 12 (9%) | 75.0% | 9 (33%) | 1 (3%) | 10 (30%) | 90.0% | 13 |
5 | Metachronous | Yes | 11 (32%) | 3 (14%) | 14 (28%) | 78.6% | 11 (37%) | 2 (21%) | 13 (35%) | 84.6% | 16 |
6 | Synchronous | No | 10 (21%) | 2 (5%) | 12 (19%) | 83.3% | 10 (35%) | 5 (12%) | 15 (27%) | 62.5% | 17 |
7 | Metachronous | Yes | 8 (46%) | 2 (22%) | 10 (41%) | 80.0% | 8 (64%) | 6 (13%) | 14 (42%) | 53.3% | 16 |
8 | Synchronous | No | 5 (71%) | 0 (NA) | 5 (71%) | 100.0% | 5 (34%) | 1 (15%) | 6 (31%) | 83.3% | 6 |
9 | Synchronous | Yes | 4 (45%) | 0 (NA) | 4 (45%) | 100.0% | 4 (29%) | 1 (7%) | 5 (25%) | 80.00% | 5 |
10 | Synchronous | Yes | 5 (51%) | 5 (10%) | 10 (31%) | 50.00% | 5 (60%) | 5 (15%) | 10 (37%) | 50.00% | 15 |
11 | Synchronous | Yes | 6 (54%) | 2 (16%) | 8 (45%) | 75.00% | 6 (41%) | 1 (19%) | 7 (38%) | 85.71% | 9 |
12 | Synchronous | No | 7 (37%) | 1 (4%) | 8 (33%) | 87.50% | 7 (39%) | 0 (NA) | 7 (39%) | 100.00% | 8 |
13 | Metachronous | No | 6 (40%) | 10 (8%) | 16 (20%) | 37.50% | 6 (58%) | 3 (12%) | 9 (43%) | 66.67% | 19 |
14 | Synchronous | No | 11 (21%) | 5 (4%) | 16 (16%) | 68.75% | 11 (18%) | 7 (15%) | 18 (17%) | 61.11% | 23 |
15 | Synchronous | Yes | 3 (72%) | 14 (17%) | 17 (26%) | 17.65% | 3 (42%) | 0 (NA) | 3 (42%) | 100.00% | 17 |
16 | Metachronous | No | 608 (12%) | 133 (9%) | 741 (11%) | 82.1% | 608 (20%) | 264 (17%) | 872 (19%) | 69.7% | 1005 |
17 | Synchronous | Yes | 10 (38%) | 1 (5%) | 11 (35%) | 90.91% | 10 (34%) | 4 (4%) | 14 (25%) | 71.43% | 15 |
18 | Synchronous | No | 9 (25%) | 3 (18%) | 12 (23%) | 75.00% | 9 (45%) | 1 (3%) | 10 (41%) | 90.00% | 13 |
Total | Â | Â | 740 (38%) | 191 (10%) | 931 (30%) | 79.4%a | 740 (39%) | 305 (13%) | 1045 (34%) | 70.8%a | 1236 |