Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are associated with expression of a stem cell related HOX-signature in glioblastoma

Table 1 Coefficients of linear models for HOX-signature expression in GBM datasets

Coefficients	Estimate	Std. Error ^a	t value ^b	Pr (>\|t\|) ^c	R ^2d	VIF ^e
NCH_EORTC (Model 1)					0.318
(Intercept)	−0.793	0.166	−4.791	1.26e-05
cg05092861	−0.453	0.110	−4.137	0.0001		1.001
CNA chr7p15.2 (BAC)	1.804	0.554	3.257	0.0019		1.001
NCH_EORTC (Model 2)					0.215
(Intercept)	−0.204	0.168	−1.212	0.231
cg01078824	−0.311	0.113	−2.754	0.008		1.002
CNA chr7p15.2 (BAC)	1.822	0.594	3.066	0.003		1.002
TCGA (Model 1)					0.289
(Intercept)	−0.612	0.105	−5.822	7.07e-08
cg05092861	−0.372	0.067	−5.542	2.44e-07		1.000
CNA chr7p15.2 (SNP6)	0.664	0.184	3.608	0.000		1.000
TCGA (Model 2)					0.254
(Intercept)	−0.158	0.088	−1.785	0.077
cg01078824	−0.356	0.071	−4.962	2.87e-06		1.023
CNA chr7p15.2 (SNP6)	0.799	0.191	4.186	6.13e-05		1.023

^aStandard error.
^bt-statistics.
^cTwo-sided P values of t-statistic.
^dR-squared provides information about the variance explained by the model.
^eVariance inflated factor (VIF), provides information about multi-collinearity of the model variables.

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