Top 20 most important features by Gini index. Gini index of the top 20 features for prediction in different genomic regions. Colors represent different types of features: neighbors in red, genomic position in green, sequence properties in blue and CREs in black. (A) Gini index for whole-genome prediction. (B) Gini index for prediction in promoter regions. (C) Gini index for prediction in CGIs. CGI, CpG island; CRE, cis-regulatory element; DHS, DNAse I hypersensitive; UpMethyl, upstream CpG site; DownMethyl, downstream CpG site; UpDist, distance in bases to the upstream CpG site; DownDist, distance in bases to the downstream CpG site.