Analysis of long non-coding RNAs highlights tissue-specific expression patterns and epigenetic profiles in normal and psoriatic skin

Table 3 Enriched (FDR ≤ 0.1) inferred functions among all the differentially expressed lncRNAs (DE lncRNAs) and differentially expressed novel lncRNAs (DE novel lncRNAs) in psoriatic skin

Enrichment		No. of genes with the function	No. of DEGs with the function	P value	FC	FDR
DE lncRNAs (total)	Cytokine activity	42	41	5.28E-12	1.91	3.72E-08
	Extracellular space	69	60	4.96E-11	1.70	3.50E-07
	Extracellular region part	87	72	7.77E-11	1.62	5.48E-07
	Cellular lipid metabolic process	68	56	1.78E-08	1.61	1.25E-04
	Fatty acid metabolic process	42	37	1.50E-07	1.72	1.05E-03
	Lipid metabolic process	87	66	4.21E-07	1.48	2.96E-03
	Monocarboxylic acid metabolic process	46	39	6.41E-07	1.66	4.51E-03
	Lipid biosynthetic process	45	38	1.11E-06	1.65	7.80E-03
	Regulation of inflammatory response	23	22	1.90E-06	1.87	1.34E-02
	Cytokine receptor interaction	34	30	2.18E-06	1.73	1.54E-02
DE novel lncRNAs	Extracellular space	69	30	3.99E-07	2.33	1.32E-03
	Extracellular region part	87	34	1.42E-06	2.09	4.72E-03
	Cytokine activity	42	20	6.80E-06	2.55	2.26E-02
	Cellular lipid metabolic process	68	27	1.34E-05	2.13	4.46E-02
	Lipid metabolic process	87	32	1.42E-05	1.97	4.72E-02
	Biosynthesis of unsaturated fatty acid	6	6	1.97E-05	5.36	6.54E-02
	Exidoreductase activity	48	21	2.14E-05	2.34	7.09E-02

FC refers to the observed to expected ratios for the enrichment. For illustration purposes, only inferred functions annotated with at most 100 genes are shown.

ISSN: 1474-760X