Genome-wide differential methylation in subcutaneous adipose. Difference in methylation (∆beta) for all CpG sites passing Bonferroni correction is plotted. ∆beta is weighted by t-statistic such that distance from central core (grey) indicates increasing levels of statistical significance. Red dots represent CpG sites hypermethylated and blue dots CpG sites hypomethylated, respectively, before weight loss. Chromosomes are shown clockwise from 1 through X.