Differential expression analysis reveals novel and known miRNAs. Differential expression for each miRNA was calculated using the Wilcoxon ranked-sum test, and P values were multiple-test corrected using the BH algorithm. (a) MA (Log ratio (M) versus mean average (A) expression) plot showing differentially expressed miRNAs comparing DLBCL to centroblasts. (b) MA plot showing miRNA that are differentially expressed between the B-cell data sets (DLBCL and centroblasts) and all other TCGA cancer data sets. In both MA plots, significantly differentially expressed known miRNAs are represented by red dots, while significantly differentially expressed candidate novel miRNAs are represented by green dots. (c) Heatmap of differentially expressed miRNAs between the ABC and GCB DLBCL subtypes. Column labels represent the type of sample: Dark Blue: ABC-DLBCL; Light Blue: GCB-DLBCL; Gray: Unclassified-DLBCL. Row labels indicate if the miRNA is more abundant in a particular category of samples.