Figure 1

Profiling miRNA in DLBCL. (a) miRNA sequence analysis identifies several small RNA species, with the majority of reads aligning to miRNA loci. The pie chart depicts the proportion and origin of miRNA-seq aligned reads. Reported proportions are averaged across the 92 DLBCL and 15 centroblast libraries. (b) Expression of candidate novel miRNA across DLBCL and centroblast libraries. Column labels represent the type of sample: Dark Blue: ABC-DLBCL; Light Blue: GCB-DLBCL; Gray: Unclassified-DLBCL; Orange: Centroblasts. Row labels are annotated to indicate whether the miRNA was more abundantly expressed in a sample category. (c) Expression of B-cell enriched candidate novel miRNAs (NOVELM00010M, miR-10398-3p and NOVELM00260M) in DLBCL, centroblasts, and other cancers. BLCA: bladder urothelial carcinoma; BRCA: breast invasive carcinoma; CESC: cervical squamous cell carcinoma and endocervical adenocarcinoma; COAD: colon adenocarcinoma; HNSC: head and neck squamous cell carcinoma; KICH: kidney chromophobe; KIRC: kidney renal clear cell carcinoma; KIRP: kidney renal papillary cell carcinoma; LGG: brain lower grade glioma; LIHC: liver hepatocellular carcinoma; LUAD: lung adenocarcinoma; LUSC: lung squamous cell carcinoma; OV: ovarian serous cystadenocarcinoma; PAAD: pancreatic adenocarcinoma; PRAD: prostate adenocarcinoma; READ: rectum adenocarcinoma; SARC: sarcoma; SKCM: skin cutaneous melanoma; STAD: stomach adenocarcinoma; THCA: thyroid carcinoma; UCEC: uterine corpus endometrial carcinoma. Blue: DLBCL; Orange: Centroblast.