Table 2 Enriched functional categories and canonical pathways for genes missing in birds
From: Conserved syntenic clusters of protein coding genes are missing in birds
A. Enriched functional categories for genes that are missing in birds | |||
|---|---|---|---|
Rank a | Enriched functional category | P value range | No. of genes |
Diseases and Disorders | Â | Â | |
1 | Cancer | 3.03E-03 - 3.69E-02 | 74 |
2 | Endocrine system disorders | 3.03E-03 - 3.69E-02 | 45 |
3 | Gastrointestinal disease | 4.59E-04 - 3.56E-02 | 40 |
4 | Inflammatory response | 1.54E-04 - 3.69E-02 | 27 |
5 | Hypersensitivity response | 3.08E-04 - 3.69E-02 | 10 |
Molecular and Cellular Functions | Â | Â | |
1 | Cellular growth and proliferation | 2.11E-04 - 3.69E-02 | 85 |
2 | Cellular assembly and organization | 7.68E-04 - 3.69E-02 | 33 |
3 | Small molecule biochemistry | 2.14E-04 - 3.69E-02 | 28 |
4 | Cellular compromise | 3.08E-04 - 3.69E-02 | 11 |
5 | Free radical scavenging | 2.14E-04 - 3.69E-02 | 3 |
Physiological System Development and Function | Â | Â | |
1 | Hematological system development and function | 1.54E-04 - 3.69E-02 | 43 |
2 | Tissue morphology | 1.54E-04 - 3.69E-02 | 26 |
3 | Nervous system development and function | 7.68E-04 - 3.69E-02 | 26 |
4 | Immune cell trafficking | 8.09E-04 - 3.69E-02 | 23 |
5 | Humoral immune response | 8.09E-04 - 1.73E-02 | 6 |
B. Enriched canonical pathways for genes that are missing in birds ( P <0.005) | |||
Rank b | Ingenuity canonical pathway | P value c | No. of genes |
1 | Protein kinase A signaling | 1.10E-03 | 13 |
2 | Cardiac hypertrophy signaling | 5.01E-04 | 10 |
3 | G-Protein coupled receptor signaling | 4.90E-03 | 9 |
4 | Cellular effects of sildenafil (Viagra) | 2.14E-04 | 8 |
5 | Estrogen-dependent breast cancer signaling | 1.05E-03 | 8 |
6 | Sertoli cell-Sertoli cell junction signaling | 1.78E-03 | 8 |
7 | Calcium signaling | 1.78E-03 | 8 |
8 | PI3K signaling in B lymphocytes | 1.12E-03 | 7 |
9 | GNRH signaling | 1.17E-03 | 7 |
10 | T cell receptor signaling | 1.35E-03 | 6 |
11 | fMLP signaling in neutrophils | 2.34E-03 | 6 |
12 | Gαs signaling | 2.45E-03 | 6 |
13 | 14-3-3-mediated signaling | 3.47E-03 | 6 |
14 | Melatonin signaling | 1.78E-03 | 5 |
15 | FLT3 signaling in hematopoietic progenitor cells | 2.29E-03 | 5 |
16 | Acute myeloid leukemia signaling | 2.75E-03 | 5 |
17 | Regulation of IL-2 expression in activated and anergic T lymphocytes | 3.09E-03 | 5 |
18 | Melanocyte development and pigmentation signaling | 3.98E-03 | 5 |
19 | α-Adrenergic signaling | 4.68E-03 | 5 |
20 | Bladder cancer signaling | 4.68E-03 | 5 |
21 | UVA-induced MAPK signaling | 4.90E-03 | 5 |
22 | Polyamine regulation in colon cancer | 2.45E-03 | 3 |