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Table 2 Enriched functional categories and canonical pathways for genes missing in birds

From: Conserved syntenic clusters of protein coding genes are missing in birds

A. Enriched functional categories for genes that are missing in birds
Rank a Enriched functional category P value range No. of genes
Diseases and Disorders   
1 Cancer 3.03E-03 - 3.69E-02 74
2 Endocrine system disorders 3.03E-03 - 3.69E-02 45
3 Gastrointestinal disease 4.59E-04 - 3.56E-02 40
4 Inflammatory response 1.54E-04 - 3.69E-02 27
5 Hypersensitivity response 3.08E-04 - 3.69E-02 10
Molecular and Cellular Functions   
1 Cellular growth and proliferation 2.11E-04 - 3.69E-02 85
2 Cellular assembly and organization 7.68E-04 - 3.69E-02 33
3 Small molecule biochemistry 2.14E-04 - 3.69E-02 28
4 Cellular compromise 3.08E-04 - 3.69E-02 11
5 Free radical scavenging 2.14E-04 - 3.69E-02 3
Physiological System Development and Function   
1 Hematological system development and function 1.54E-04 - 3.69E-02 43
2 Tissue morphology 1.54E-04 - 3.69E-02 26
3 Nervous system development and function 7.68E-04 - 3.69E-02 26
4 Immune cell trafficking 8.09E-04 - 3.69E-02 23
5 Humoral immune response 8.09E-04 - 1.73E-02 6
B. Enriched canonical pathways for genes that are missing in birds ( P <0.005)
Rank b Ingenuity canonical pathway P value c No. of genes
1 Protein kinase A signaling 1.10E-03 13
2 Cardiac hypertrophy signaling 5.01E-04 10
3 G-Protein coupled receptor signaling 4.90E-03 9
4 Cellular effects of sildenafil (Viagra) 2.14E-04 8
5 Estrogen-dependent breast cancer signaling 1.05E-03 8
6 Sertoli cell-Sertoli cell junction signaling 1.78E-03 8
7 Calcium signaling 1.78E-03 8
8 PI3K signaling in B lymphocytes 1.12E-03 7
9 GNRH signaling 1.17E-03 7
10 T cell receptor signaling 1.35E-03 6
11 fMLP signaling in neutrophils 2.34E-03 6
12 Gαs signaling 2.45E-03 6
13 14-3-3-mediated signaling 3.47E-03 6
14 Melatonin signaling 1.78E-03 5
15 FLT3 signaling in hematopoietic progenitor cells 2.29E-03 5
16 Acute myeloid leukemia signaling 2.75E-03 5
17 Regulation of IL-2 expression in activated and anergic T lymphocytes 3.09E-03 5
18 Melanocyte development and pigmentation signaling 3.98E-03 5
19 α-Adrenergic signaling 4.68E-03 5
20 Bladder cancer signaling 4.68E-03 5
21 UVA-induced MAPK signaling 4.90E-03 5
22 Polyamine regulation in colon cancer 2.45E-03 3
  1. aRanking by number of avian missing genes within each enrichment category type.
  2. bRanking by number of avian missing genes associated with the pathway.
  3. cThe complete list of functions associated with these categories is presented in Additional file 1: Table S9.