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Figure 7 | Genome Biology

Figure 7

From: Conserved syntenic clusters of protein coding genes are missing in birds

Figure 7

Assessing the functional impact of the avian missing genes in the context of the chicken, human, and lizard genomes. Comparative functional enrichment analysis was used to compare the impact of the same set of avian missing genes against the genetics backgrounds of chicken, humans, and lizard. Gene Ontology (GO) term enrichments for pairwise comparison were identified by Fisher’s test (P <0.05), and a Venn diagram was used to compare the GO term enrichments and identify: Group A, terms significantly enriched in non-avian species but not in birds (yellow panels), representing functions/pathways that might be disrupted only if the gene loss were to have occurred in non-avian organisms; Group B1, terms enriched in birds only (dark blue), representing functions/pathways that might be affected only in the context of avian genomes; Group B2, enriched terms shared between birds and humans and/or lizard (green), representing pathways that would be affected in multiple or all species, and for which there are no apparent compensations in these species; and Group C, terms enriched in chicken and lizard (gray), representing functions that would in principle be affected in sauropsids but likely not in mammals, possibly due to compensation in the latter.

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