Figure 3

Distribution of avian missing genes and syntenic blocks on human and lizard chromosomes. (A) Plots showing the numbers of avian missing syntenic blocks present on human (left) and lizard (right) chromosomes. In both species, the observed number of deletions per chromosomes is significantly different from a predicted uniform distribution based on chromosome size (Chi-squared test for independence). (B) Plot showing the numbers of missing genes on human (left) and lizard (right) chromosomes. In both species, the observed number of deletions per chromosomes is significantly different from a predicted uniform distribution based on chromosome size (Chi-squared test for independence). (C) Plot showing the percentage of missing genes, normalized by the number of 1-to-1 (lizard-to-human) orthologs, on each chromosome. (D) Plot showing the percentage of missing genes, normalized by the total number of missing genes on each chromosome in human (left; black bars) and lizard (right; black bars). Gray bars indicate the relative percentage of deletions for each chromosome that would be expected if the deletions occurred at according to a random distribution similar to the loss of avian missing genes in blocks and as singletons (see Methods for details). Lizard microchromosome LGe was excluded from the analysis because it contained coding genes predictions. Abbreviations: Un, unplaced segments in lizard genome.