Table 1 EML4-ALK co-occurring fusion genes and chimeric transcripts detected with TRUP 1.0
PatID | HistoID | Chimeric_transcript | Sp | Enc | Total | Type-I | Type-II | Domains | Validated |
|---|---|---|---|---|---|---|---|---|---|
H2228 | Cell-line | EML4-ALK_v3 | 8 (8 + 8) | 13 | 21 | Intra | IF | Protein_kinase | . |
SND1-CFTR | 6 (6 + 4) | 5 | 11 | Intra | IF | Snase/ABC_tran | RT-PCR | ||
DCBLD2-STXBP5L | 7 (7 + 2) | 2 | 9 | Intra | IF | CUB/LCCL/F5_F8_type_C | RT-PCR | ||
H3122 | Cell-line | SOS1-ADCY3 | 16 (16 + 15) | 16 | 32 | Intra | IF | RhoGEF/Guanylate_cyc | RT-PCR |
EML4-ALK_v1 | 22 (22 + 7) | 9 | 31 | Intra | IF | Protein_kinase | . | ||
S00006 | AD | EML4-ALK_v2 | 15 (15 + 4) | 5 | 20 | Intra | IF | Protein_kinase | FISH |
S00054 | AD | EML4-ALK_v1 | 24 (24 + 16) | 30 | 54 | Intra | IF | Protein_kinase | FISH |
PIGF-CHMP3 | 13 (13 + 0) | 4 | 17 | Intra | IF | Snf7 | RT-PCR | ||
SNAP29-CELSR1 | 8 (8 + 2) | 6 | 14 | Intra | IF | EGF/LamininG2/LamininEGF/HRM/GPS/7tm2 | RT-PCR | ||
APOBEC3F-SBF1 | 4 (4 + 0) | 1 | 5 | Not validated | |||||
S01122 | AD | EML4-ALK_v1 | 29 (29 + 8) | 12 | 41 | Intra | IF | Protein_kinase | FISH |
BMI1-ABI1 | 14 (14 + 4) | 7 | 21 | Intra | OF | . | RT-PCR | ||
MYO10-GPC5 | 12 (12 + 0) | 0 | 12 | Inter | IF | Myosin_head/IQ/PH | RT-PCR | ||
ARHGEF7-ZDHHC11 | 8 (8 + 2) | 0 | 8 | Inter | IF | CH/SH3/RhoGEF | RT-PCR | ||
S01124 | AD | EML4-ALK_v1 | 0 | 4 | 4 | Intra | IF | Protein_kinase | FISH |
TAF4-LSM14B | 12 (12 + 1) | 2 | 14 | Intra | IF | FDF | RT-PCR | ||
S01320 | AD | EML4-ALK_v1 | 21 (21 + 7) | 6 | 27 | Intra | IF | Protein_kinase | FISH |
NUP85-GPC3 | 12 (12 + 2) | 0 | 12 | Inter | IF | Nucleopor_Nup85 | RT-PCR | ||
NR2C1-PTPRB | 15 (15 + 4) | 4 | 19 | Not validated | |||||
KRIT-MAGI2 | 2 (2 + 3) | 3 | 5 | Not validated |