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Figure 2 | Genome Biology

Figure 2

From: MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

Figure 2

A comparison of MAGeCK with two other RNA interference screen algorithms, RIGER and RSA. (a) The numbers of significantly selected genes identified by MAGeCK, RIGER and RSA in different comparisons. For comparisons between control samples or between replicates of the same condition (highlighted in yellow), ideally no significantly selected genes should be detected. Comparisons between treatments and controls are highlighted in green. See Table S1 in Additional file 2 for a complete comparison. (b) The overlap of top-ranked genes between CRISPR/Cas9 knockout screening and RNAi screening on the melanoma dataset. The positive screening experiment was performed in the same way as for the melanoma dataset [17], except that pooled shRNA screening was used instead of CRISPR/Cas9 knockout screening.

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