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Table 2 QTL statistics for the IgA traits in the G 10 mouse population

From: Host genetics and diet, but not immunoglobulin A expression, converge to shape compositional features of the gut microbiome in an advanced intercross population of mice

Trait IghV gene Ch Location (Mb) CI (Mb) LOD A d % Interaction
B182 IghV2-6-1 1 70.1 69.2-73.1 4.21 0.206 0.166 6.44  
B48 IghV14-4 4 117.5 106.0-124.5 4.64* 0.037 -0.234 6.66  
   12 112.3 108.8-118.1 4.63* 0.210 -0.082 8.60  
B30 IghV1-26 6 137.8 130.6-143.3 4.59* 0.221 0.112 8.91  
   12 114.5 109.1-120.0 3.94 0.147 -0.022 7.47  
B122 IghV1S17 7 4.3 3.6-16.2 4.57* -0.139 0.188 7.22  
B81 IghV1-75 8 91.5 90.6-92.8 4.07 0.144 0.367 6.51 Sex (M,F)
   12 114.5 114.0-120.0 21.29* -0.530 0.257 38.01  
   19 42.8 42.1-47.7 3.94 -0.197 0.199 5.67  
B207 IghV5-12-1 9 27.3 18.8-32.9 3.98 -0.081 -0.325 6.37  
   12 114.5 114.0-120.0 26.11* 0.689 0.306 42.76  
B218 IghV5-6-2 9 22.8 13.7-31.8 4.13 -0.067 -0.351 6.65  
   12 114.5 114.0-120.0 24.85* 0.701 0.271 41.87  
B44 IghV14-2 12 114.5 114.0-120.0 13.74* -0.325 0.128 23.17  
B76 IghV1-7 12 114.5 114.0-120.0 5.07* 0.158 -0.036 9.55  
B88 IghV1-81 12 114.5 114.0-120.0 19.31* -0.472 0.174 36.27  
B89 IghV1-82 12 114.5 110.9-120.0 5.07* 0.160 0.019 10.26  
B57 IghV1-52 12 114.5 114.0-120.0 4.78* 0.187 -0.027 9.63  
B23 IghV1-22 12 114.5 114.0-120.0 10.35* -0.028 0.009 20.36  
B17 IghV1-20 12 114.5 114.0-120.0 13.74* 0.344 0.030 26.70  
B37 IghV1-34 12 114.5 114.0-120.0 26.32* 0.540 0.258 43.19  
B14 IghV1-18 12 114.5 114.0-120.0 14.55* -0.337 0.141 28.03  
B80 IghV1-74 12 112.3 108.8-118.1 6.12* -0.256 0.058 11.84  
B42 IghV1-4 12 114.5 114.0-120.0 15.14* -0.432 0.142 27.61  
B71 IghV1-63 12 114.5 114.0-120.0 7.87* 0.300 0.069 14.67  
B91 IghV1-84 12 114.5 114.0-120.0 23.21* 0.505 0.170 40.59  
B72 IghV1-64 12 114.5 114.0-120.0 42.12* -0.728 0.446 55.90  
B54 IghV1-5 12 114.5 114.0-120.0 12.00* 0.361 0.061 23.32  
   13 37.6 35.4-41.8 4.50* -0.213 0.031 8.41  
B87 IghV1-80 12 114.5 114.0-120.0 34.33* -0.700 0.488 49.98  
B15 IghV1-19 12 114.5 114.0-120.0 8.66* -0.294 0.171 16.25  
B78 IghV1-71 12 114.5 114.0-120.0 5.45* -0.279 0.083 9.80  
B93 IghV1-9 12 114.5 114.0-120.0 52.78* -0.913 0.630 70.88  
B61 IghV1-55 12 114.5 114.0-120.0 43.09* -0.791 0.484 61.04  
B79 IghV1-72 12 114.5 114.0-120.0 46.20* -0.846 0.558 61.53  
B73 IghV1-66 12 114.5 114.0-120.0 12.00* -0.382 0.108 22.15  
B43 IghV14-1 12 114.5 114.0-120.0 9.53* -0.386 0.194 16.72  
B55 IghV1-50 12 114.5 118.3-120.9 13.31* -0.436 0.166 22.83  
B46 IghV14-3 12 114.5 114.0-120.0 52.85* 0.979 0.529 65.56  
   18 82.1 77.7-84.3 4.48* -0.421 0.675 11.98  
B92 IghV1-85 12 114.5 114.0-120.0 31.70* -0.794 0.465 51.35  
B64 IghV1-59 12 114.5 114.0-120.0 15.30* -0.541 0.172 26.78  
B60 IghV1-54 12 114.5 114.0-120.0 27.34* -0.699 0.537 45.98  
B82 IghV1-76 12 114.5 114.0-120.0 29.75* -0.606 0.338 48.99  
B10 IghV1-14 12 114.5 114.0-120.0 29.75* 1.098 0.843 69.66  
B40 IghV1-37 12 114.5 110.9-120.0 4.02 0.230 -0.048 7.37  
B153 IghV1S61 12 114.5 114.0-120.0 62.17* 1.189 0.733 74.98  
B234 IghV6-3 12 114.5 114.0-120.0 5.60* -0.235 0.154 11.23  
B83 IghV1-77 12 114.5 114.0-120.0 15.01* -0.400 0.254 28.59  
B114 IghV1S135 12 114.5 114.0-120.0 43.97* 0.988 0.471 64.30  
B217 IghV5-6-1 12 114.5 114.0-120.0 34.60* -0.766 0.438 54.28  
B223 IghV5-9 12 114.5 114.0-120.0 19.14* 0.544 0.280 33.41  
B63 IghV1-58 12 114.5 114.0-120.0 22.02* -0.667 0.222 38.12  
B189 IghV2-6-8 12 114.5 114.0-120.0 9.23* 0.376 0.098 16.43  
B175 IghV2-3 12 114.5 114.0-120.0 14.48* -0.481 0.277 26.82  
B196 IghV3-4 12 114.5 112.3-120.0 12.45* 0.445 0.100 24.31  
B75 IghV1-69 17 33.7 31.6-38.0 4.70* 0.177 0.108 8.02  
B195 IghV3-3 17 33.7 31.9-42.6 12.83* 0.348 0.394 18.80  
   17 45.6 43.6-48.7 12.81* 0.447 0.495 29.33  
   18 82.1 79.6-84.3 6.38* -0.445 0.724 18.79  
B178 IghV2-4-1 18 53.9 52.9-58.5 4.25* 0.089 0.173 6.98  
B59 IghV1-53 19 42.1 37.9-42.8 4.20 -0.008 -0.118 5.73  
  1. Shown are all QTLs affecting the IgA traits that had LOD scores reaching the suggestive or significant (*) experiment-wise level of significance. The chromosome (Ch) location of the peak and confidence intervals (CI) of each QTL is given in Mb (from NCBI Build 37). Also shown is the percentage contribution (%) of each QTL to the total variance of each trait, and its additive (a), dominance (d) genotypic effects (bolded values indicate significance). Sex (M,F) = an interaction of the QTL with sex, where the QTL is significant in both sexes but has a greater effect in females.
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