Mark enrichment levels are correlated with gene expression levels in human. (A) Density of enrichment level for five marks around TSSs for genes with low, medium, and high expression levels. Values are averaged across individuals and across genes in each category. (B) Mark enrichment levels plotted against gene expression levels for sliding windows of genes (n = 200) ordered from low to high expression levels. Enrichment levels are obtained in ±2 kb regions near TSSs and scaled to be between 0 and 1. All values are averaged across individuals and across genes in the window. (C) Proportion of variance in gene expression levels explained (R squared) by individual marginal effects (five colored bars), combined mark marginal effects (grey bars), all first-order interaction effects in addition to marginal effects (black bars), and all chromatin state-specific effects in addition to marginal effects (white bars) of the five marks. Results are shown for enrichment levels in TSS regions with increasing length. Error bars indicate standard deviation calculated based on 20 split replicates.