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Figure 4 | Genome Biology

Figure 4

From: Prioritizing causal disease genes using unbiased genomic features

Figure 4

OPEN scores for DCM successfully prioritize genes at loci identified through a GWA study for left ventricular diameter (LVD). OPEN scores for DCM were mapped to genes at loci marginally associated with LVD (P < 5 × 10-5). Eleven loci have a high-scoring top-ranked gene based on OPEN scores for DCM association. Blue coloring indicates the seven genes are mutated in Mendelian forms of cardiac disease, including DCM, HCM, arrhythmogenic right ventricular cardiomyopathy and catecholaminergic polymorphic ventricular tachycardia (P = 8 × 10-5 for enrichment).

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