Figure 3
From: Prioritizing causal disease genes using unbiased genomic features
OPEN successfully predicts cardiomyopathy genes. (A) ROC curves for hypertrophic cardiomyopathy (HCM, left) and dilated cardiomyopathy (DCM, right). (B) Top ranked genes according to OPEN score for HCM. Log-odds of disease association are obtained through cross-validation. Blue bars represent positive training examples. (C) OPEN scores for DCM (as a Mendelian disease) are useful for prioritizing genes at DCM GWA loci. Each locus is represented by a scatter plot of OPEN score against chromosomal position, with every gene at the locus represented by a circle. Gene symbols for top ranked genes are provided. Purple coloring indicates that BAG3 has already been implicated in a Mendelian form of DCM.