The relative density of 5mC and 5hmC within genomic regions. (A) The relative density indicates the ratio between 5mC or 5hmC and all inspected ‘CCGG’ sites within each genomic region. (B) The relative mRNA levels of UHRF1, TET1, 2, and 3 in HCCs and adjacent non-HCC liver tissues tested by RT-qPCR. (C) The expression of TET2 and UHRF1 protein in HCCs and adjacent non-HCC liver tissues using western blot. β-actin was used as loading control.