Figure 9

HeV sensitizes PaKiT03 cells to TRAIL-mediated apoptosis. Cells were either treated with 500 ng/ml human recombinant TRAIL and/or infected with virus (MOI = 5) for 24, 48 and 72 hpi. The activities of caspase 3/7 within the experimental samples were compared to the control (no TRAIL or virus) using one-way analysis of variance for each time point. *P <0.05, **P <0.01. All assays were performed in triplicate. (A) Increase of caspase 3/7 activity over control in PaKiT03 cells following stimulation with human recombinant TRAIL and/or HeV. (B) Increase of caspase 3/7 activity over control in HEK293T cells following stimulation with human recombinant TRAIL and/or Nelson Bay virus (NBV).