Table 1 Summary of SEARCH cohort

Number of patients

245

35

50

97

62

27

Age at diagnosis (years)

57 (8.2)

53.9 (11.8)

53.4 (12.4)

54.5 (9.4)

55.8 (7.4)

56.2 (9)

Entry time (months)

23.5 (18.9 to 32.1)

26.4 (19.6 to 33.5)

28 (18.2 to 47.6)

28.7 (21.2 to 46.4)

29.4 (19.4 to 59.6)

27.8 (23.1 to 31.6)

Last follow-up time (months)

71.1 (45.4 to 105.6)

126.5 (85.7 to 149.1)

123 (83.1 to 170.3)

140.9 (86.5 to 171.2)

144.8 (101.6 to 208.2)

97.8 (73.7 to 139.7)

Vital status

Data available

245 (100%)

35 (100%)

50 (100%)

97 (100%)

62 (100%)

27 (100%)

Alive

89 (36%)

27 (77%)

39 (78%)

69 (71%)

47 (76%)

16 (59%)

Died

156 (64%)

8 (23%)

11 (22%)

28 (29%)

15 (24%)

11 (41%)

Stage

Data available

238 (97%)

33 (94%)

47 (94%)

96 (99%)

62 (100%)

24 (89%)

I

46 (19%)

27 (82%)

42 (89%)

76 (79%)

50 (81%)

13 (54%)

II

27 (11%)

2 (6%)

1 (2%)

13 (14%)

6 (10%)

5 (21%)

III

139 (58%)

4 (12%)

4 (9%)

6 (6%)

5 (8%)

5 (21%)

IV

26 (11%)

0 (0%)

0 (0%)

1 (1%)

1 (2%)

1 (4%)

Grade

Data available

201 (82%)

13 (37%)

26 (52%)

78 (80%)

26 (42%)

11 (41%)

I

1 (0%)

11 (85%)

10 (38%)

22 (28%)

2 (8%)

1 (9%)

II

56 (28%)

1 (8%)

14 (54%)

40 (51%)

11 (42%)

7 (64%)

III

144 (72%)

1 (8%)

2 (8%)

16 (21%)

13 (50%)

3 (27%)

PTEN status (IF)

Data available

214 (87%)

29 (83%)

41 (82%)

89 (92%)

59 (95%)

26 (96%)

Negative

49 (23%)

2 (7%)

12 (29%)

39 (44%)

34 (58%)

8 (31%)

Weak positive

68 (32%)

6 (21%)

11 (27%)

27 (30%)

18 (31%)

8 (31%)

Heterogeneous

48 (22%)

7 (24%)

2 (5%)

3 (3%)

1 (2%)

3 (12%)

Positive

49 (23%)

14 (48%)

16 (39%)

20 (22%)

6 (10%)

7 (27%)

PTEN status (IHC)

Data available

211 (86%)

28 (80%)

44 (88%)

90 (93%)

56 (90%)

26 (96%)

Negative

53 (25%)

3 (11%)

9 (20%)

35 (39%)

22 (39%)

4 (15%)

Weak positive

73 (35%)

8 (29%)

5 (11%)

28 (31%)

18 (32%)

5 (19%)

Heterogeneous

34 (16%)

3 (11%)

6 (14%)

6 (7%)

3 (5%)

3 (12%)

Positive

51 (24%)

14 (50%)

24 (55%)

21 (23%)

13 (23%)

14 (54%)