Figure 3
From: Characterizing heterogeneity in leukemic cells using single-cell gene expression analysis
Mapping cellular hierarchy using SPADE analysis. (A) The cellular hierarchy in the normal hematopoietic system is represented by the SPADE tree (adapted from [20]), on which the leukemic and normal cells are mapped as described in the main text. Open circles denote clusters to which no cells were mapped. The size of each non-empty node is scaled according to the associated number of cells. The branches corresponding to HSC, GMP, and dendritic cell (DC)/macrophage lineages according to [20] are labeled. (B) The mean expression levels for four select genes are overlaid on the SPADE tree.