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Table 8 The performance of models developed from one-platform in predicting microarray and RNA-Seq validation samples based on the TCGA AML data

From: An investigation of biomarkers derived from legacy microarray data for their utility in the RNA-seq era

Algorithm Direction End point Gene set Microarray data RNA-Seq data T-index
Accuracy AUC Accuracy AUC
Mean 95% CI Mean 95% CI Mean 95% CI Mean 95% CI
k-NN Forward Sex A 0.988 0.988-0.988 0.987 0.987-0.987 0.977 0.977-0.977 0.977 0.977-0.977 0.977
B 0.978 0.942-0.988 0.978 0.945-0.987 0.869 0.523-0.988 0.857 0.481-0.987 0.851
Cyto Risk A 0.939 0.895-0.988 0.884 0.805-0.993 0.916 0.837-0.977 0.825 0.68-0.979 0.917
B 0.931 0.837-0.977 0.890 0.69-0.986 0.914 0.837-0.965 0.903 0.736-0.979 0.914
Reverse Sex A 0.895 0.895-0.895 0.885 0.885-0.885 0.988 0.988-0.988 0.987 0.987-0.987 0.896
B 0.512 0.419-0.593 0.503 0.426-0.58 0.508 0.407-0.593 0.509 0.409-0.6 0.510
Cyto Risk A 0.920 0.866-0.988 0.864 0.736-0.993 0.949 0.837-0.988 0.916 0.822-0.993 0.921
B 0.447 0.186-0.849 0.609 0.5-0.802 0.850 0.767-0.919 0.747 0.587-0.896 0.425
NSC Forward Sex A 0.988 0.988-0.988 0.987 0.987-0.987 0.978 0.977-0.988 0.978 0.977-0.987 0.978
  B 0.982 0.977-0.988 0.981 0.977-0.987 0.988 0.988-0.988 0.987 0.987-0.987 0.988
Cyto Risk A 0.931 0.872-0.953 0.840 0.656-0.899 0.927 0.86-0.977 0.828 0.649-0.962 0.927
B 0.884 0.826-0.919 0.843 0.676-0.923 0.888 0.872-0.892 0.885 0.815-0.912 0.888
Reverse Sex A 0.977 0.977-0.977 0.974 0.974-0.974 0.988 0.988-0.988 0.987 0.987-0.987 0.977
B 0.523 0.442-0.558 0.502 0.472-0.553 0.508 0.442-0.558 0.486 0.438-0.539 0.516
Cyto Risk A 0.906 0.837-0.965 0.788 0.635-0.947 0.924 0.895-0.953 0.893 0.839-0.968 0.907
B 0.663 0.198-0.919 0.704 0.5-0.854 0.819 0.814-0.837 0.520 0.5-0.579 0.653
SVM Forward Sex A 0.984 0.977-0.988 0.983 0.977-0.987 0.713 0.453-0.988 0.737 0.5-0.987 0.641
B 0.981 0.93-0.988 0.981 0.934-0.987 0.817 0.488-0.988 0.799 0.45-0.987 0.782
Cyto Risk A 0.925 0.86-0.965 0.849 0.736-0.93 0.909 0.837-0.988 0.787 0.611-0.993 0.910
B 0.950 0.831-0.977 0.916 0.66-0.986 0.935 0.849-0.977 0.924 0.704-0.986 0.935
Reverse Sex A 0.603 0.547-0.698 0.563 0.5-0.667 0.986 0.977-0.988 0.985 0.974-0.987 0.587
B 0.510 0.453-0.547 0.500 0.458-0.549 0.500 0.407-0.599 0.499 0.401-0.6 0.505
Cyto Risk A 0.897 0.826-0.977 0.777 0.562-0.979 0.961 0.924-0.988 0.945 0.837-0.993 0.896
B 0.789 0.535-0.814 0.487 0.339-0.5 0.874 0.767-0942 0.798 0.61-0.94 0.793
  1. AUC: Area under ROC curve; CI: Confidence interval; 95% CI was calculated from the bootstrap estimation.