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Table 8 The performance of models developed from one-platform in predicting microarray and RNA-Seq validation samples based on the TCGA AML data

From: An investigation of biomarkers derived from legacy microarray data for their utility in the RNA-seq era

Algorithm

Direction

End point

Gene set

Microarray data

RNA-Seq data

T-index

Accuracy

AUC

Accuracy

AUC

Mean

95% CI

Mean

95% CI

Mean

95% CI

Mean

95% CI

k-NN

Forward

Sex

A

0.988

0.988-0.988

0.987

0.987-0.987

0.977

0.977-0.977

0.977

0.977-0.977

0.977

B

0.978

0.942-0.988

0.978

0.945-0.987

0.869

0.523-0.988

0.857

0.481-0.987

0.851

Cyto Risk

A

0.939

0.895-0.988

0.884

0.805-0.993

0.916

0.837-0.977

0.825

0.68-0.979

0.917

B

0.931

0.837-0.977

0.890

0.69-0.986

0.914

0.837-0.965

0.903

0.736-0.979

0.914

Reverse

Sex

A

0.895

0.895-0.895

0.885

0.885-0.885

0.988

0.988-0.988

0.987

0.987-0.987

0.896

B

0.512

0.419-0.593

0.503

0.426-0.58

0.508

0.407-0.593

0.509

0.409-0.6

0.510

Cyto Risk

A

0.920

0.866-0.988

0.864

0.736-0.993

0.949

0.837-0.988

0.916

0.822-0.993

0.921

B

0.447

0.186-0.849

0.609

0.5-0.802

0.850

0.767-0.919

0.747

0.587-0.896

0.425

NSC

Forward

Sex

A

0.988

0.988-0.988

0.987

0.987-0.987

0.978

0.977-0.988

0.978

0.977-0.987

0.978

 

B

0.982

0.977-0.988

0.981

0.977-0.987

0.988

0.988-0.988

0.987

0.987-0.987

0.988

Cyto Risk

A

0.931

0.872-0.953

0.840

0.656-0.899

0.927

0.86-0.977

0.828

0.649-0.962

0.927

B

0.884

0.826-0.919

0.843

0.676-0.923

0.888

0.872-0.892

0.885

0.815-0.912

0.888

Reverse

Sex

A

0.977

0.977-0.977

0.974

0.974-0.974

0.988

0.988-0.988

0.987

0.987-0.987

0.977

B

0.523

0.442-0.558

0.502

0.472-0.553

0.508

0.442-0.558

0.486

0.438-0.539

0.516

Cyto Risk

A

0.906

0.837-0.965

0.788

0.635-0.947

0.924

0.895-0.953

0.893

0.839-0.968

0.907

B

0.663

0.198-0.919

0.704

0.5-0.854

0.819

0.814-0.837

0.520

0.5-0.579

0.653

SVM

Forward

Sex

A

0.984

0.977-0.988

0.983

0.977-0.987

0.713

0.453-0.988

0.737

0.5-0.987

0.641

B

0.981

0.93-0.988

0.981

0.934-0.987

0.817

0.488-0.988

0.799

0.45-0.987

0.782

Cyto Risk

A

0.925

0.86-0.965

0.849

0.736-0.93

0.909

0.837-0.988

0.787

0.611-0.993

0.910

B

0.950

0.831-0.977

0.916

0.66-0.986

0.935

0.849-0.977

0.924

0.704-0.986

0.935

Reverse

Sex

A

0.603

0.547-0.698

0.563

0.5-0.667

0.986

0.977-0.988

0.985

0.974-0.987

0.587

B

0.510

0.453-0.547

0.500

0.458-0.549

0.500

0.407-0.599

0.499

0.401-0.6

0.505

Cyto Risk

A

0.897

0.826-0.977

0.777

0.562-0.979

0.961

0.924-0.988

0.945

0.837-0.993

0.896

B

0.789

0.535-0.814

0.487

0.339-0.5

0.874

0.767-0942

0.798

0.61-0.94

0.793

  1. AUC: Area under ROC curve; CI: Confidence interval; 95% CI was calculated from the bootstrap estimation.