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Table 6 The performance of k-NN models in predicting microarray and RNA-Seq validation samples based on the SEQC NB data

From: An investigation of biomarkers derived from legacy microarray data for their utility in the RNA-seq era

Direction End point Gene set Predicto mg microarray validation data Predicting RNA-Seq validation data T-index
Accuracy AUC Accuracy AUC
Mean 95% CI Mean 95% CI Mean 95% CI Mean 95% CI
Models developed from microarray A* A 0.728 0.659-0.775 0.698 0.633-0.752 0.706 0.606-0.763 0.678 0.596-0.747 0.712
B 0.730 0.655-0.775 0.694 0.619-0.749 0.709 0.640-0.755 0.671 0.610-0.730 0.714
B* A 0.786 0.751-0.815 0.662 0.600-0.719 0.792 0.743-0.831 0.621 0.547-0.738 0.791
B 0.785 0.743-0.821 0.638 0.572-0.708 0.764 0.663-0.815 0.621 0.521-0.737 0.768
C* A 0.988 0.983-0.992 0.988 0.983-0.992 0.990 0.975-0.992 0.990 0.977-0.992 0.990
B 0.982 0.971-0.992 0.983 0.974-0.992 0.984 0.975-0.992 0.985 0.976-0.995 0.984
D* A 0.928 0.860-0.971 0.907 0.831-0.962 0.890 0.790-0.949 0.860 0.728-0.937 0.891
B 0.918 0.816-0.982 0.900 0.781-0.978 0.868 0.746-0.956 0.841 0.736-0.945 0.870
E* A 0.625 0.522-0.711 0.540 0.446-0.637 0.627 0.456-0.733 0.529 0.440-0.636 0.626
B 0.564 0.456-0.661 0.489 0.394-0.573 0.516 0.278-0.711 0.497 0.429-0.575 0.533
F* A 0.516 0.433-0.600 0.515 0.432-0.597 0.532 0.433-0.622 0.521 0.438-0.607 0.525
B 0.493 0.422-0.556 0.497 0.430-0.562 0.512 0.422-0.600 0.495 0.415-0.575 0.503
Models developed from RNA-Seq A* A 0.655 0.456-0.759 0.653 0.528-0.752 0.695 0.610-0.747 0.656 0.586-0.714 0.665
B 0.551 0.367-0.719 0.572 0.421-0.705 0.692 0.614-0.747 0.651 0.575-0.710 0.584
B* A 0.778 0.715-0.811 0.571 0.516-0.636 0.776 0.735-0.815 0.641 0.583-0.704 0.777
B 0.740 0.524-0.807 0.643 0.500-0.768 0.775 0.723-0.815 0.629 0.556-0.698 0.746
C* A 0.991 0.979-0.992 0.991 0.981-0.992 0.992 0.992-0.992 0.991 0.992-0.992 0.991
B 0.797 0.797-0.801 0.823 0.822-0.826 0.987 0.979-0.992 0.987 0.981-0.992 0.796
D* A 0.862 0.651-0.956 0.832 0.632-0.945 0.914 0.846-0.956 0.896 0.809-0.946 0.863
B 0.781 0.408-0.941 0.812 0.548-0.937 0.910 0.824-0.956 0.890 0.782-0.946 0.775
E* A 0.538 0.333-0.689 0.546 0.452-0.632 0.606 0.478-0.706 0.526 0.432-0.618 0.560
B 0.607 0.400-0.722 0.502 0.420-0.609 0.593 0.500-0.689 0.511 0.419-0.615 0.603
F* A 0.491 0.411-0.584 0.500 0.421-0.588 0.497 0.405-0.589 0.495 0.401-0.588 0.494
B 0538 0.456-0.600 0.505 0.440-0585 0.492 0.411-0.567 0.502 0.424-0.574 0.516