Figure 7
Differential DNA methylation is associated with altered expression of microRNAs and their target genes in female compared with male human islets. (A) Decreased DNA methylation of five CpG sites as well as increased expression (males n = 5, females n = 6) of hsa-miR-660 in female compared with male islets. Also, potential target genes of hsa-miR-660 showed lower gene expression in female compared with male human islets. (B) Decreased DNA methylation as well as increased expression (males n = 4, females n = 7) of hsa-miR-532 in female compared with male islets. Also, potential target genes showed lower gene expression in female compared with male human islets. Data are presented as mean ± standard error of the mean. Asterisks indicate q <0.05 for DNA methylation data and P <0.05 for gene expression data.