Figure 1

Females and males cluster separately based on DNA methylation in human pancreatic islets. (A) An unsupervised clustering analysis of the genome-wide DNA methylation data for all analyzed sites that passed quality control in human islets of 53 male and 34 female donors, after batch correction. The clustering includes 482,954 sites. Females are indicated with red color and (F), and males are indicated with blue color and (M). (B) An unsupervised clustering analysis of the genome-wide DNA methylation data including only autosomal data that passed quality control in human islets from 53 male and 34 female donors, after batch correction. Removal of X-chromosome DNA methylation data makes females and males cluster together. The clustering includes 471,804 sites. Females are indicated with red color and (F), and males are indicated with blue color and (M).